{"id":23330,"date":"2023-04-23T22:05:47","date_gmt":"2023-04-23T19:05:47","guid":{"rendered":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease.png"},"modified":"2023-04-23T22:06:04","modified_gmt":"2023-04-23T19:06:04","slug":"oxidative-stress-and-mitochondrial-dysfunction-in-chronic-kidney-disease","status":"inherit","type":"attachment","link":"https:\/\/yaronmargolin.com\/?attachment_id=23330","title":{"rendered":"Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease"},"author":1,"comment_status":"open","ping_status":"closed","template":"","meta":[],"description":{"rendered":"<p class=\"attachment\"><a href='https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease.png'><img width=\"300\" height=\"213\" src=\"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-300x213.png\" class=\"attachment-medium size-medium\" alt=\"\" decoding=\"async\" srcset=\"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-300x213.png 300w, https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-768x545.png 768w, https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-100x71.png 100w, https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-150x106.png 150w, https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-200x142.png 200w, https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-450x319.png 450w, https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-600x426.png 600w, https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-900x638.png 900w, https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease.png 939w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n"},"caption":{"rendered":"<p> \u05de\u05ea\u05d7 \u05d7\u05de\u05e6\u05d5\u05e0\u05d9 (\u05d9\u05d9\u05e6\u05d5\u05e8 \u05de\u05d5\u05d2\u05d1\u05e8 \u05e9\u05dc mtROS) \u05e2\u05d5\u05de\u05d3 \u05de\u05d0\u05d7\u05e8\u05d9 \u05ea\u05e4\u05e7\u05d5\u05d3 \u05dc\u05e7\u05d5\u05d9 \u05e9\u05dc \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d4, \u05e9\u05d1\u05e1\u05d5\u05e4\u05d5 \u05e9\u05dc \u05d3\u05d1\u05e8 \u05d2\u05d5\u05e8\u05dd \u05dc\u05e0\u05d6\u05e7 \u05dc\u05ea\u05d0\u05d9\u05dd \u05d5\u05dc\u05d4\u05ea\u05e7\u05d3\u05de\u05d5\u05ea \u05e9\u05dc \u05de\u05d7\u05dc\u05ea \u05db\u05dc\u05d9\u05d5\u05ea, \u05d1\u05e8\u05d0\u05e9\u05d9\u05ea \u05d4\u05e0\u05d6\u05e7 \u05e8\u05d5\u05d0\u05d9\u05dd \u05d0\u05d5\u05d1\u05d3\u05df \u05e9\u05dc \u05e0\u05e4\u05e8\u05d5\u05df, \u05e0\u05d6\u05e7 \u05e9\u05d4\u05d5\u05dc\u05da \u05d5\u05de\u05ea\u05d2\u05d1\u05e8 \u05d5\u05de\u05d5\u05d1\u05d9\u05dc \u05dc\u05d0\u05d9 \u05e1\u05e4\u05d9\u05e7\u05ea \u05db\u05dc\u05d9\u05d5\u05ea [\u05de\u05e7\u05d5\u05e8]. \u05d4\u05de\u05e7\u05d5\u05e8\u05d5\u05ea \u05d4\u05e2\u05d9\u05e7\u05e8\u05d9\u05d9\u05dd \u05dc\u05d4\u05d9\u05d5\u05d5\u05e6\u05e8\u05d5\u05ea\u05d5 \u05e1\u05d9\u05e0\u05d8\u05d6\u05d4 \u05e9\u05dc \u05de\u05d9\u05e0\u05d9 \u05d7\u05de\u05e6\u05df \u05ea\u05d2\u05d5\u05d1\u05ea\u05d9\u05d9\u05dd -reactive oxygen species (ROS) \u05d0\u05e0\u05d3\u05d5\u05d2\u05e0\u05d9 \u05d1\u05db\u05dc\u05d9\u05d4 \u05d7\u05e9\u05d5\u05d1\u05d4 \u05dc\u05d4\u05d1\u05e0\u05ea \u05d4\u05d1\u05e1\u05d9\u05e1 \u05dc\u05de\u05d7\u05dc\u05d4 \u05d5\u05dc\u05d3\u05e8\u05db\u05d9 \u05d4\u05d7\u05dc\u05de\u05ea\u05d4. \u05e0\u05de\u05e6\u05d0 \u05e9\u05d4\u05de\u05ea\u05d7 \u05d4\u05d7\u05d9\u05de\u05e6\u05d5\u05e0\u05d9 \u05de\u05ea\u05d7\u05d9\u05dc \u05d5\u05de\u05ea\u05e8\u05d7\u05e9\u05ea \u05d1\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d4 \u05d5\u05d1\u05de\u05e9\u05e4\u05d7\u05ea \u05d4-NADPH \u05d0\u05d5\u05e7\u05e1\u05d9\u05d3\u05d0\u05d6 (NOX) &#8211; \u05d0\u05e0\u05d6\u05d9\u05dd \u05d4\u05de\u05d6\u05e8\u05d6 \u05ea\u05d2\u05d5\u05d1\u05d4 \u05e9\u05dc \u05d7\u05de\u05e6\u05d5\u05df-\u05d7\u05d6\u05d5\u05e8 [\u05de\u05e7\u05d5\u05e81, \u05de\u05e7\u05d5\u05e82, \u05de\u05e7\u05d5\u05e83]. \u05d1\u05ea\u05e0\u05d0\u05d9\u05dd \u05e4\u05d9\u05d6\u05d9\u05d5\u05dc\u05d5\u05d2\u05d9\u05d9\u05dd \u05e8\u05d2\u05d9\u05dc\u05d9\u05dd, \u05e0\u05e7\u05d1\u05d5\u05d1\u05d9\u05d5\u05ea \u05d4\u05de\u05e2\u05d1\u05e8 \u05d1\u05d7\u05d3\u05d9\u05e8\u05ea \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d4 &#8211; mPTP \u05de\u05d0\u05e4\u05e9\u05e8\u05d5\u05ea \u05dc\u05d7\u05d5\u05de\u05e8\u05d9\u05dd \u05e7\u05d8\u05e0\u05d9\u05dd \u05dc\u05e0\u05d5\u05e2 \u05d0\u05dc \u05ea\u05d5\u05da \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d4 \u05d5\u05dc\u05d4\u05e0\u05d9\u05e2 ATP \u05e1\u05d9\u05e0\u05ea\u05d0\u05d6 [\u05d1\u05d0\u05de\u05e6\u05e2\u05d5\u05ea \u05d6\u05e8\u05d7\u05d5\u05df \u05d7\u05de\u05e6\u05d5\u05e0\u05d9 (OXPHOS)] \u05db\u05da \u05e0\u05e9\u05de\u05e8 \u05e4\u05d5\u05d8\u05e0\u05e6\u05d9\u05d0\u05dc \u05d4\u05de\u05de\u05d1\u05e8\u05e0\u05d4 \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d0\u05dc\u05d9 MMP (\u0394\u03a8(m)) [\u05d1\u05d0\u05de\u05e6\u05e2\u05d5\u05ea \u05d4\u05d2\u05d1\u05e8\u05d4 \u05e9\u05dc \u05d9\u05d5\u05df \u05d4\u05e1\u05d9\u05d3\u05df \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d0\u05dc\u05d9 (Ca2+) \u05db\u05e0\u05e8\u05d0\u05d4 \u05d1\u05d0\u05d9\u05d5\u05e8 \u05dc\u05de\u05e2\u05dc\u05d4]. \u05dc\u05e2\u05d5\u05de\u05ea \u05d6\u05d0\u05ea, \u05d1\u05de\u05e6\u05d1\u05d9\u05dd \u05e4\u05ea\u05d5\u05e4\u05d9\u05d6\u05d9\u05d5\u05dc\u05d5\u05d2\u05d9\u05d9\u05dd, \u05de\u05e9\u05ea\u05d1\u05e9 \u05d4\u05de\u05e2\u05d1\u05e8 \u05d4\u05d6\u05d4 &#8211;  \u05dc\u05d7\u05e5 \u05d7\u05de\u05e6\u05d5\u05e0\u05d9 \u05de\u05d5\u05d2\u05d1\u05e8 \u05d0\u05d5 \u05e2\u05d5\u05de\u05e1 \u05d9\u05ea\u05e8 \u05e9\u05dc Ca2+ \u05de\u05e2\u05d5\u05e8\u05e8 \u05e4\u05ea\u05d9\u05d7\u05ea mPTP \u05d1\u05d0\u05d5\u05e4\u05df \u05d7\u05e8\u05d9\u05d2. \u05d4\u05e4\u05ea\u05d7 \u05d2\u05d3\u05dc \u05db\u05ea\u05d5\u05e6\u05d0\u05d4 \u05de\u05db\u05da, \u05d5\u05de\u05e2\u05d1\u05e8 \u05e9\u05dc \u05d7\u05d5\u05de\u05e8\u05d9\u05dd \u05d2\u05d3\u05d5\u05dc\u05d9\u05dd \u05d5\u05d7\u05d5\u05de\u05e8\u05d9\u05dd \u05de\u05e1\u05d9\u05e1\u05d9\u05dd \u05e9\u05dc\u05d0 \u05d0\u05de\u05d5\u05e8\u05d9\u05dd \u05dc\u05d7\u05d3\u05d5\u05e8 \u05dc\u05de\u05e8\u05d7\u05d1 \u05d4\u05e2\u05d3\u05d9\u05df \u05e9\u05d1\u05ea\u05d5\u05da \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d4 \u05e0\u05db\u05e0\u05e1\u05d9\u05dd \u05d5\u05d2\u05d5\u05e8\u05de\u05d9\u05dd \u05dc\u05e7\u05e8\u05d9\u05e1\u05ea \u05e4\u05d5\u05d8\u05e0\u05e6\u05d9\u05d0\u05dc \u05d4\u05de\u05de\u05d1\u05e8\u05e0\u05d4 \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d0\u05dc\u05d9 (MMP) \u05d5\u05d1\u05de\u05e7\u05e8\u05d4 \u05e9\u05dc\u05e4\u05e0\u05d9\u05e0\u05d5 \u05de\u05ea\u05d7\u05d9\u05dc\u05d4 \u05e7\u05e8\u05d9\u05e1\u05ea \u05d4\u05e0\u05e4\u05e8\u05d5\u05df. \u05de\u05ea\u05e8\u05d7\u05e9 \u05e0\u05d9\u05ea\u05d5\u05e7 \u05e9\u05dc \u05d6\u05e8\u05d7\u05d5\u05df \u05d7\u05de\u05e6\u05d5\u05e0\u05d9 OXPHOS \u05d5\u05e0\u05e4\u05d9\u05d7\u05d5\u05ea \u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d0\u05dc\u05d9\u05ea. \u05d1\u05e0\u05d5\u05e1\u05e3, \u05de\u05d6\u05d4\u05d9\u05dd \u05e9\u05d7\u05e8\u05d5\u05e8 \u05de\u05d5\u05de\u05e8\u05e5 \u05e9\u05dc \u05e6\u05d9\u05d8\u05d5\u05db\u05e8\u05d5\u05dd c \u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d0\u05dc\u05d9 (cyt c) \u05d5\u05d4\u05d5\u05d0 \u05e2\u05d5\u05d1\u05e8 \u05dc\u05ea\u05d5\u05da \u05d4\u05e6\u05d9\u05d8\u05d5\u05e4\u05dc\u05d6\u05de\u05d4 \u05d5\u05de\u05e2\u05d5\u05e8\u05e8 \u05de\u05d5\u05d5\u05ea \u05e9\u05dc \u05ea\u05d0\u05d9\u05dd \u05d0\u05e4\u05d5\u05e4\u05d8\u05d5\u05d8\u05d9\u05d9\u05dd [\u05de\u05e7\u05d5\u05e81, \u05de\u05e7\u05d5\u05e82]. \u05dc\u05e4\u05ea\u05d9\u05d7\u05ea \u05e0\u05e7\u05d1\u05d5\u05d1\u05d9\u05d5\u05ea \u05d4\u05de\u05e2\u05d1\u05e8 \u05d1\u05d7\u05d3\u05d9\u05e8\u05ea \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d4 (mPTP) \u05d1\u05de\u05d9\u05d3\u05d4 \u05d4\u05e0\u05db\u05d5\u05e0\u05d4 \u05d9\u05e9 \u05ea\u05e4\u05e7\u05d9\u05d3 \u05e4\u05d9\u05d6\u05d9\u05d5\u05dc\u05d5\u05d2\u05d9 \u05d7\u05e9\u05d5\u05d1 \u05d1\u05e9\u05de\u05d9\u05e8\u05d4 \u05e2\u05dc \u05d4\u05d5\u05de\u05d0\u05d5\u05e1\u05d8\u05d6\u05d9\u05e1 \u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d0\u05dc\u05d9 \u05d1\u05e8\u05d9\u05d0.  <\/p>\n<div class=\"read-more\"><a href=\"https:\/\/yaronmargolin.com\/?attachment_id=23330\">\u05e7\u05e8\u05d0 \u05e2\u05d5\u05d3 &#8250;<\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n"},"alt_text":"","media_type":"image","mime_type":"image\/png","media_details":{"width":939,"height":666,"file":"2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease.png","sizes":{"medium":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-300x213.png","width":300,"height":213,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-300x213.png"},"thumbnail":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-150x150.png","width":150,"height":150,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-150x150.png"},"medium_large":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-768x545.png","width":768,"height":545,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-768x545.png"},"responsive-100":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-100x71.png","width":100,"height":71,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-100x71.png"},"responsive-150":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-150x106.png","width":150,"height":106,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-150x106.png"},"responsive-200":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-200x142.png","width":200,"height":142,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-200x142.png"},"responsive-300":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-300x213.png","width":300,"height":213,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-300x213.png"},"responsive-450":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-450x319.png","width":450,"height":319,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-450x319.png"},"responsive-600":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-600x426.png","width":600,"height":426,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-600x426.png"},"responsive-900":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-900x638.png","width":900,"height":638,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease-900x638.png"},"full":{"file":"Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease.png","width":939,"height":666,"mime_type":"image\/png","source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease.png"}},"image_meta":{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0","keywords":[]}},"post":23312,"source_url":"https:\/\/yaronmargolin.com\/wp-content\/uploads\/2023\/04\/Oxidative-Stress-and-Mitochondrial-Dysfunction-in-Chronic-Kidney-Disease.png","_links":{"self":[{"href":"https:\/\/yaronmargolin.com\/index.php?rest_route=\/wp\/v2\/media\/23330"}],"collection":[{"href":"https:\/\/yaronmargolin.com\/index.php?rest_route=\/wp\/v2\/media"}],"about":[{"href":"https:\/\/yaronmargolin.com\/index.php?rest_route=\/wp\/v2\/types\/attachment"}],"author":[{"embeddable":true,"href":"https:\/\/yaronmargolin.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/yaronmargolin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23330"}]}}