{"id":32711,"date":"2026-03-25T14:29:24","date_gmt":"2026-03-25T12:29:24","guid":{"rendered":"https:\/\/yaronmargolin.com\/?p=32711"},"modified":"2026-03-27T12:01:52","modified_gmt":"2026-03-27T09:01:52","slug":"%f0%9f%87%af%f0%9f%87%b5-%e8%85%8e%e6%a9%9f%e8%83%bd%e3%81%a8%e5%85%a8%e8%ba%ab%e3%81%ae%e5%81%a5%e5%ba%b7%e3%81%ab%e9%96%a2%e3%82%8f%e3%82%8b%e7%94%9f%e4%bd%93%e8%aa%bf%e7%af%80%e3%83%a1%e3%82%ab","status":"publish","type":"post","link":"https:\/\/yaronmargolin.com\/?p=32711","title":{"rendered":"\ud83c\uddef\ud83c\uddf5 \u814e\u6a5f\u80fd\u3068\u5168\u8eab\u306e\u5065\u5eb7\u306b\u95a2\u308f\u308b\u751f\u4f53\u8abf\u7bc0\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u6982\u8981"},"content":{"rendered":"\n

\u05e2\u05d1\u05e8\u05d9\u05ea<\/a><\/strong>, Spanish \u2013 Espa\u00f1ol<\/a>, \u0420\u0443\u0441\u0441\u043a\u0438\u0439<\/a>, Deutsch<\/a>, English<\/a><\/strong><\/strong>, \u65e5\u672c\u8a9e<\/a><\/strong>.<\/p>\n\n\n\n

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\"\"<\/a>
\ud83c\uddef\ud83c\uddf5 \u814e\u6a5f\u80fd\u3068\u5168\u8eab\u306e\u5065\u5eb7\u306b\u95a2\u308f\u308b\u751f\u4f53\u8abf\u7bc0\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u6982\u8981<\/figcaption><\/figure>\n<\/figure>\n\n\n\n

\u6162\u6027\u814e\u81d3\u75c5\u306f\u4e00\u822c\u306b\u6a5f\u80fd\u4f4e\u4e0b\u306e\u9032\u884c\u3068\u3057\u3066\u7406\u89e3\u3055\u308c\u307e\u3059\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u751f\u4f53\u5185\u306e\u8abf\u7bc0\u30fb\u7dad\u6301\u6a5f\u69cb\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u672c\u7a3f\u3067\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3001\u7d30\u80de\u4fdd\u8b77\u3068\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3001\u8840\u6d41\u3068\u5168\u8eab\u74b0\u5883\u3068\u3044\u3046\u4e09\u3064\u306e\u8ef8\u304b\u3089\u3001\u814e\u6a5f\u80fd\u3092\u652f\u3048\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6574\u7406\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\uff08\u203b \u751f\u4f53\u306e\u5185\u5728\u7684\u306a\u8abf\u7bc0\u6a5f\u69cb\u306b\u7740\u76ee\u3057\u305f\u6982\u5ff5\u30e2\u30c7\u30eb\uff09<\/p>\n\n\n\n

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\ud83d\udcca \u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7d71\u5408<\/h2>\n\n\n\n

\u672c\u7a3f\u3067\u8ff0\u3079\u305f\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3001\u305d\u306e\u8abf\u6574\u306e\u53ef\u80fd\u6027\u3092\u6574\u7406\u3059\u308b\u305f\u3081\u306b\u3001\u4ee5\u4e0b\u306b\u7d71\u5408\u7684\u306a\u8868\u3092\u793a\u3059\u3002<\/p>\n\n\n\n

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\u88681\uff1a\u814e\u6a5f\u80fd\u304a\u3088\u3073\u5168\u8eab\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u4e3b\u8981\u306a\u751f\u7269\u5b66\u7684\u7d4c\u8def<\/h3>\n\n\n\n
\u7d4c\u8def<\/th>\u814e\u81d3\u306b\u304a\u3051\u308b\u4e3b\u306a\u6a5f\u80fd<\/th>\u8abf\u6574\u306e\u53ef\u80fd\u6027<\/th>\u95a2\u9023\u3059\u308b\u4ed6\u306e\u81d3\u5668<\/th><\/tr><\/thead>
AMPK \u2192 SIRT1 \u2192 PGC-1\u03b1<\/td>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u65b0\u751f\uff1b\u7d30\u80de\u4fdd\u8b77<\/td>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff1b\u904b\u52d5\uff1b\u9593\u6b20\u7684\u65ad\u98df<\/td>\u5fc3\u81d3\u3001\u8133\u3001\u809d\u81d3\u3001\u80ba<\/td><\/tr>
Nrf2\u2013Keap1<\/td>\u6297\u9178\u5316\u9632\u5fa1\uff1b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u4f4e\u6e1b<\/td>\u30b9\u30eb\u30d5\u30a9\u30e9\u30d5\u30a1\u30f3\uff08\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\u30b9\u30d7\u30e9\u30a6\u30c8\uff09\uff1b\u30af\u30eb\u30af\u30df\u30f3<\/td>\u809d\u81d3\u3001\u8178\u3001\u5fc3\u81d3\u3001\u8133<\/td><\/tr>
\u30df\u30c8\u30d5\u30a1\u30b8\u30fc\uff0f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc + TFEB<\/td>\u640d\u50b7\u6210\u5206\u306e\u9664\u53bb\uff1b\u7d30\u80de\u6052\u5e38\u6027\u7dad\u6301<\/td>\u30a6\u30ed\u30ea\u30c1\u30f3A\uff1b\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff1b\u30b9\u30eb\u30d5\u30a9\u30e9\u30d5\u30a1\u30f3<\/td>\u809d\u81d3\u3001\u5fc3\u81d3\u3001\u8133\u3001\u80ba<\/td><\/tr>
FGF23\u2013Klotho<\/td>\u30df\u30cd\u30e9\u30eb\u30d0\u30e9\u30f3\u30b9\u8abf\u6574\uff1b\u6297\u7dda\u7dad\u5316\u4f5c\u7528<\/td>\u30d3\u30bf\u30df\u30f3D\uff08\u614e\u91cd\u306b\uff09\uff1b\u904b\u52d5<\/td>\u5fc3\u81d3\u3001\u8133<\/td><\/tr>
\u8178\u2013\u814e\u8ef8<\/td>\u6bd2\u7d20\u8ca0\u8377\u306e\u4f4e\u6e1b\uff1b\u708e\u75c7\u306e\u8abf\u6574<\/td>\u30b9\u30eb\u30d5\u30a9\u30e9\u30d5\u30a1\u30f3\uff1b\u30a6\u30ed\u30ea\u30c1\u30f3A\uff1b\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u30b5\u30a4\u30ea\u30a6\u30e0\u3001\u30ec\u30b8\u30b9\u30bf\u30f3\u30c8\u30b9\u30bf\u30fc\u30c1\u3001\u30b0\u30eb\u30b3\u30de\u30f3\u30ca\u30f3\u3014\u30b3\u30f3\u30cb\u30e3\u30af\u7531\u6765\u3015\uff09\uff1b\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9<\/td>\u8178\u3001\u809d\u81d3\u3001\u5fc3\u81d3\u3001\u8133<\/td><\/tr>
HPT\u8ef8<\/td>\u4ee3\u8b1d\u8abf\u6574\uff08T3\uff09<\/td>\u904b\u52d5\uff1b\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/td>\u8133\u3001\u809d\u81d3\u3001\u5fc3\u81d3<\/td><\/tr>
mTORC1<\/td>\u7d30\u80de\u6210\u9577\u306e\u5236\u5fa1<\/td>AMPK\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u8abf\u6574\uff1b\u9593\u6b20\u7684\u65ad\u98df<\/td>\u7b4b\u8089\u3001\u809d\u81d3<\/td><\/tr>
Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3<\/td>\u7dda\u7dad\u5316\u306b\u95a2\u4e0e<\/td>\u30af\u30eb\u30af\u30df\u30f3\uff1b\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/td>\u809d\u81d3\u3001\u5fc3\u81d3<\/td><\/tr>
NO \/ eNOS<\/td>\u8840\u6d41\u8abf\u6574\uff1b\u8840\u7ba1\u6a5f\u80fd<\/td>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff1b\u30a6\u30c1\u30ef\u30b5\u30dc\u30c6\u30f3\uff08Opuntia\uff09\uff1b\u30d6\u30ed\u30e1\u30e9\u30a4\u30f3\uff08\u30d1\u30a4\u30ca\u30c3\u30d7\u30eb\uff09<\/td>\u5fc3\u81d3\u3001\u8133\u3001\u80ba<\/td><\/tr>
\u30a4\u30ea\u30b7\u30f3 \/ FNDC5<\/td>\u904b\u52d5\u306b\u3088\u308b\u4fdd\u8b77\u4f5c\u7528<\/td>\u904b\u52d5<\/td>\u8133\u3001\u5fc3\u81d3<\/td><\/tr>
PPAR\u03b1<\/td>\u8102\u8cea\u4ee3\u8b1d\u8abf\u6574<\/td>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff1b\u904b\u52d5<\/td>\u809d\u81d3\u3001\u5fc3\u81d3<\/td><\/tr>
\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u8abf\u7bc0<\/td>\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u9577\u671f\u5236\u5fa1<\/td>SIRT1\u6d3b\u6027\u5316\uff1b\u30b9\u30eb\u30d5\u30a9\u30e9\u30d5\u30a1\u30f3\uff1b\u904b\u52d5<\/td>\u5168\u8eab<\/td><\/tr>
\u30d3\u30bf\u30df\u30f3D \/ VDR<\/td>\u514d\u75ab\u8abf\u6574\uff1b\u814e\u4fdd\u8b77<\/td>\u30d3\u30bf\u30df\u30f3D\uff08\u7ba1\u7406\u4e0b\uff09\uff1b\u65e5\u5149<\/td>\u9aa8\u3001\u514d\u75ab\u7cfb\u3001\u8178<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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\u6ce8\u8a18\uff1a<\/strong>
\u672c\u8868\u306f\u79d1\u5b66\u7684\u77e5\u898b\u306b\u57fa\u3065\u304f\u6982\u5ff5\u7684\u6574\u7406\u3067\u3042\u308a\u3001\u533b\u7642\u7684\u52a9\u8a00\u3092\u76ee\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

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\u672c\u8868\u306f\u6559\u80b2\u7684\u30fb\u6982\u5ff5\u7684\u306a\u6574\u7406\u3092\u76ee\u7684\u3068\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u6cbb\u7642\u3092\u63a8\u5968\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/strong><\/p>\n\n\n\n

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\u05e2\u05d1\u05e8\u05d9\u05ea<\/a>,\u00a0Spanish \u2013 Espa\u00f1ol<\/a>,\u00a0\u0420\u0443\u0441\u0441\u043a\u0438\u0439<\/a>,\u00a0Deutsch<\/a>,\u00a0English<\/a><\/strong><\/strong>, \u65e5\u672c\u8a9e<\/a><\/strong>.<\/strong><\/strong><\/p>\n\n\n\n

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\ud83d\udcda \u53c2\u8003\u6587\u732e\uff08References\uff09<\/h1>\n\n\n\n

\ud83d\udd0b \u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068\u518d\u751f\uff08Energy and Regeneration\uff09<\/h2>\n\n\n\n
    \n
  1. Hallan S, Sharma K. The role of mitochondria in diabetic kidney disease. Nat Rev Nephrol<\/em>.<\/li>\n\n\n\n
  2. Bhargava P, Schnellmann RG. Mitochondrial energetics in the kidney. Nat Rev Nephrol<\/em>.<\/li>\n\n\n\n
  3. Hardie DG. AMPK: a key regulator of energy balance in the kidney. Physiol Rev<\/em>.<\/li>\n\n\n\n
  4. Cant\u00f3 C, Auwerx J. Targeting sirtuin 1 to improve metabolism. Nat Rev Drug Discov<\/em>.<\/li>\n\n\n\n
  5. Hasegawa K et al. SIRT1 protects against oxidative stress in kidney disease. J Am Soc Nephrol<\/em>.<\/li>\n\n\n\n
  6. Scarpulla RC. PGC-1\u03b1 and mitochondrial biogenesis. Cell Metab<\/em>.<\/li>\n\n\n\n
  7. Kume S et al. Role of nutrient-sensing pathways in diabetic nephropathy. J Am Soc Nephrol<\/em>.<\/li>\n\n\n\n
  8. Martins R et al. FOXO proteins and aging. Aging Cell<\/em>.<\/li>\n\n\n\n
  9. Cheng Z et al. SIRT1\/FOXO pathway in renal protection. Kidney Int<\/em>.<\/li>\n\n\n\n
  10. Verdin E. NAD\u207a metabolism and aging. Science<\/em>.<\/li>\n<\/ol>\n\n\n\n
    \n\n\n\n

    \ud83d\udee1\ufe0f \u7d30\u80de\u4fdd\u8b77\u3068\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\uff08Protection and Clearance\uff09<\/h2>\n\n\n\n
      \n
    1. Yamamoto M et al. The KEAP1\u2013NRF2 system: a master regulator of oxidative stress. Physiol Rev<\/em>.<\/li>\n\n\n\n
    2. Ruiz S et al. Targeting the Nrf2 pathway in kidney disease. Kidney Int<\/em>.<\/li>\n\n\n\n
    3. Ding Y, Choi ME. Autophagy in diabetic nephropathy. J Endocrinol<\/em>.<\/li>\n\n\n\n
    4. Livingston MJ et al. Autophagy in acute kidney injury and repair. J Clin Invest<\/em>.<\/li>\n\n\n\n
    5. Kimura T et al. Autophagy and the kidney. Nat Rev Nephrol<\/em>.<\/li>\n\n\n\n
    6. Pickles S et al. Mitophagy and mitochondrial quality control. Nat Rev Mol Cell Biol<\/em>.<\/li>\n\n\n\n
    7. Settembre C et al. TFEB links autophagy to lysosomal biogenesis. Science<\/em>.<\/li>\n\n\n\n
    8. Mizushima N. Autophagy: process and function. Genes Dev<\/em>.<\/li>\n<\/ol>\n\n\n\n
      \n\n\n\n

      \ud83c\udf0a \u74b0\u5883\u30fb\u8840\u6d41\u30fb\u5168\u8eab\u76f8\u4e92\u4f5c\u7528\uff08Environment, Flow, and Systemic Interaction\uff09<\/h2>\n\n\n\n
        \n
      1. F\u00f6rstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J<\/em>.<\/li>\n\n\n\n
      2. Vanhoutte PM et al. Endothelial dysfunction and vascular disease. Acta Physiol<\/em>.<\/li>\n\n\n\n
      3. Crowley SD, Coffman TM. The inextricable role of the kidney in hypertension. J Clin Invest<\/em>.<\/li>\n\n\n\n
      4. Mezzano SA et al. Renin-angiotensin system and renal fibrosis. Kidney Int Suppl<\/em>.<\/li>\n\n\n\n
      5. Fine LG, Norman JT. Chronic hypoxia as a mechanism of kidney disease progression. Kidney Int<\/em>.<\/li>\n\n\n\n
      6. Haase VH. Hypoxia-inducible factors in kidney disease. J Am Soc Nephrol<\/em>.<\/li>\n\n\n\n
      7. Ruiz-Ortega M et al. TGF-\u03b2 signaling in renal fibrosis. Nat Rev Nephrol<\/em>.<\/li>\n\n\n\n
      8. Evenepoel P et al. The gut-kidney axis. Nat Rev Nephrol<\/em>.<\/li>\n\n\n\n
      9. Vaziri ND et al. CKD alters gut microbiome and toxin generation. Kidney Int<\/em>.<\/li>\n\n\n\n
      10. Tang WHW et al. Gut microbiota and cardiovascular disease (TMAO pathway). N Engl J Med<\/em>.<\/li>\n<\/ol>\n\n\n\n
        \n\n\n\n

        \ud83d\udd39 \u6162\u6027\u814e\u75be\u60a3\u304a\u3088\u3073\u7dda\u7dad\u5316\u306b\u95a2\u3059\u308b\u88dc\u8db3\u6587\u732e\uff08CKD and Fibrosis\uff09<\/h2>\n\n\n\n
          \n
        1. Kalantar-Zadeh K et al. Chronic kidney disease. Lancet<\/em>.<\/li>\n\n\n\n
        2. Levin A et al. Kidney disease: global burden and management. Lancet<\/em>.<\/li>\n\n\n\n
        3. Ruiz S, Pergola PE, Zager RA. Targeting oxidative stress in CKD. Kidney Int<\/em>.<\/li>\n\n\n\n
        4. Nath KA. Tubulointerstitial changes as a major determinant in CKD. Kidney Int<\/em>.<\/li>\n\n\n\n
        5. Friedman SL et al. Mechanisms of fibrosis across organs. J Clin Invest<\/em>.<\/li>\n<\/ol>\n\n\n\n
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          \u3054\u8cea\u554f\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/h2>\n\n\n\n

          \u4ee5\u4e0b\u306e\u9023\u7d61\u5148\u3092\u901a\u3058\u3066\u3001\u30e4\u30ed\u30f3\u30fb\u30de\u30eb\u30b4\u30ea\u30f3\u306b\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n\n

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