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ๆ ขๆง่ ่็ ใฏไธ่ฌใซๆฉ่ฝไฝไธใฎ้ฒ่กใจใใฆ็่งฃใใใพใใใ่ฟๅนดใฎ็ ็ฉถใงใฏใ็ไฝๅ ใฎ่ชฟ็ฏใป็ถญๆๆฉๆงใ้่ฆใชๅฝนๅฒใๆใใใใจใ็คบๅใใใฆใใพใใ
ๆฌ็จฟใงใฏใใจใใซใฎใผไปฃ่ฌใ็ดฐ่ไฟ่ญทใจใฏใชใขใฉใณในใ่กๆตใจๅ จ่บซ็ฐๅขใจใใไธใคใฎ่ปธใใใ่ ๆฉ่ฝใๆฏใใใกใซใใบใ ใๆด็ใใพใใ
๏ผโป ็ไฝใฎๅ ๅจ็ใช่ชฟ็ฏๆฉๆงใซ็็ฎใใๆฆๅฟตใขใใซ๏ผ
๐ ็็ฉๅญฆ็ใกใซใใบใ ใฎ็ตฑๅ
ๆฌ็จฟใง่ฟฐในใ็็ฉๅญฆ็ใกใซใใบใ ใจใใใฎ่ชฟๆดใฎๅฏ่ฝๆงใๆด็ใใใใใซใไปฅไธใซ็ตฑๅ็ใช่กจใ็คบใใ
่กจ1๏ผ่ ๆฉ่ฝใใใณๅ จ่บซ่ชฟ็ฏใซ้ขใใไธป่ฆใช็็ฉๅญฆ็็ต่ทฏ
| ็ต่ทฏ | ่ ่ใซใใใไธปใชๆฉ่ฝ | ่ชฟๆดใฎๅฏ่ฝๆง | ้ข้ฃใใไปใฎ่ๅจ |
|---|---|---|---|
| AMPK โ SIRT1 โ PGC-1ฮฑ | ใใใณใณใใชใขๆฐ็๏ผ็ดฐ่ไฟ่ญท | ใฌในใใฉใใญใผใซ๏ผ้ๅ๏ผ้ๆฌ ็ๆญ้ฃ | ๅฟ่ใ่ณใ่่ใ่บ |
| Nrf2โKeap1 | ๆ้ ธๅ้ฒๅพก๏ผ้ ธๅในใใฌในไฝๆธ | ในใซใใฉใฉใใกใณ๏ผใใญใใณใชใผในใใฉใฆใ๏ผ๏ผใฏใซใฏใใณ | ่่ใ่ ธใๅฟ่ใ่ณ |
| ใใใใกใธใผ๏ผใชใผใใใกใธใผ + TFEB | ๆๅทๆๅใฎ้คๅป๏ผ็ดฐ่ๆๅธธๆง็ถญๆ | ใฆใญใชใใณA๏ผใฌในใใฉใใญใผใซ๏ผในใซใใฉใฉใใกใณ | ่่ใๅฟ่ใ่ณใ่บ |
| FGF23โKlotho | ใใใฉใซใใฉใณใน่ชฟๆด๏ผๆ็ท็ถญๅไฝ็จ | ใใฟใใณD๏ผๆ ้ใซ๏ผ๏ผ้ๅ | ๅฟ่ใ่ณ |
| ่ ธโ่ ่ปธ | ๆฏ็ด ่ฒ ่ทใฎไฝๆธ๏ผ็็ใฎ่ชฟๆด | ในใซใใฉใฉใใกใณ๏ผใฆใญใชใใณA๏ผใใฌใใคใชใใฃใฏใน๏ผใตใคใชใฆใ ใใฌใธในใฟใณใในใฟใผใใใฐใซใณใใณใใณใใณใณใใฃใฏ็ฑๆฅใ๏ผ๏ผใใญใใคใชใใฃใฏใน | ่ ธใ่่ใๅฟ่ใ่ณ |
| HPT่ปธ | ไปฃ่ฌ่ชฟๆด๏ผT3๏ผ | ้ๅ๏ผใฌในใใฉใใญใผใซ | ่ณใ่่ใๅฟ่ |
| mTORC1 | ็ดฐ่ๆ้ทใฎๅถๅพก | AMPK็ต่ทฏใไปใใ่ชฟๆด๏ผ้ๆฌ ็ๆญ้ฃ | ็ญ่ใ่่ |
| Wnt/ฮฒ-ใซใใใณ | ็ท็ถญๅใซ้ขไธ | ใฏใซใฏใใณ๏ผใฌในใใฉใใญใผใซ | ่่ใๅฟ่ |
| NO / eNOS | ่กๆต่ชฟๆด๏ผ่ก็ฎกๆฉ่ฝ | ใใชใใงใใผใซ๏ผใฆใใฏใตใใใณ๏ผOpuntia๏ผ๏ผใใญใกใฉใคใณ๏ผใใคใใใใซ๏ผ | ๅฟ่ใ่ณใ่บ |
| ใคใชใทใณ / FNDC5 | ้ๅใซใใไฟ่ญทไฝ็จ | ้ๅ | ่ณใๅฟ่ |
| PPARฮฑ | ่่ณชไปฃ่ฌ่ชฟๆด | ใฌในใใฉใใญใผใซ๏ผ้ๅ | ่่ใๅฟ่ |
| ใจใใธใงใใใฃใใฏ่ชฟ็ฏ | ้บไผๅญ็บ็พใฎ้ทๆๅถๅพก | SIRT1ๆดปๆงๅ๏ผในใซใใฉใฉใใกใณ๏ผ้ๅ | ๅ จ่บซ |
| ใใฟใใณD / VDR | ๅ ็ซ่ชฟๆด๏ผ่ ไฟ่ญท | ใใฟใใณD๏ผ็ฎก็ไธ๏ผ๏ผๆฅๅ | ้ชจใๅ ็ซ็ณปใ่ ธ |
ๆณจ่จ๏ผ
ๆฌ่กจใฏ็งๅญฆ็็ฅ่ฆใซๅบใฅใๆฆๅฟต็ๆด็ใงใใใๅป็็ๅฉ่จใ็ฎ็ใจใใใใฎใงใฏใใใพใใใ
ๆฌ่กจใฏๆ่ฒ็ใปๆฆๅฟต็ใชๆด็ใ็ฎ็ใจใใฆใใใ็นๅฎใฎๆฒป็ใๆจๅฅจใใใใฎใงใฏใใใพใใใ
ืขืืจืืช,ย Spanish โ Espaรฑol,ย ะ ัััะบะธะน,ย Deutsch,ย English, ๆฅๆฌ่ช.
๐ ๅ่ๆ็ฎ๏ผReferences๏ผ
๐ ใจใใซใฎใผไปฃ่ฌใจๅ็๏ผEnergy and Regeneration๏ผ
- Hallan S, Sharma K. The role of mitochondria in diabetic kidney disease. Nat Rev Nephrol.
- Bhargava P, Schnellmann RG. Mitochondrial energetics in the kidney. Nat Rev Nephrol.
- Hardie DG. AMPK: a key regulator of energy balance in the kidney. Physiol Rev.
- Cantรณ C, Auwerx J. Targeting sirtuin 1 to improve metabolism. Nat Rev Drug Discov.
- Hasegawa K et al. SIRT1 protects against oxidative stress in kidney disease. J Am Soc Nephrol.
- Scarpulla RC. PGC-1ฮฑ and mitochondrial biogenesis. Cell Metab.
- Kume S et al. Role of nutrient-sensing pathways in diabetic nephropathy. J Am Soc Nephrol.
- Martins R et al. FOXO proteins and aging. Aging Cell.
- Cheng Z et al. SIRT1/FOXO pathway in renal protection. Kidney Int.
- Verdin E. NADโบ metabolism and aging. Science.
๐ก๏ธ ็ดฐ่ไฟ่ญทใจใฏใชใขใฉใณใน๏ผProtection and Clearance๏ผ
- Yamamoto M et al. The KEAP1โNRF2 system: a master regulator of oxidative stress. Physiol Rev.
- Ruiz S et al. Targeting the Nrf2 pathway in kidney disease. Kidney Int.
- Ding Y, Choi ME. Autophagy in diabetic nephropathy. J Endocrinol.
- Livingston MJ et al. Autophagy in acute kidney injury and repair. J Clin Invest.
- Kimura T et al. Autophagy and the kidney. Nat Rev Nephrol.
- Pickles S et al. Mitophagy and mitochondrial quality control. Nat Rev Mol Cell Biol.
- Settembre C et al. TFEB links autophagy to lysosomal biogenesis. Science.
- Mizushima N. Autophagy: process and function. Genes Dev.
๐ ็ฐๅขใป่กๆตใปๅ จ่บซ็ธไบไฝ็จ๏ผEnvironment, Flow, and Systemic Interaction๏ผ
- Fรถrstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J.
- Vanhoutte PM et al. Endothelial dysfunction and vascular disease. Acta Physiol.
- Crowley SD, Coffman TM. The inextricable role of the kidney in hypertension. J Clin Invest.
- Mezzano SA et al. Renin-angiotensin system and renal fibrosis. Kidney Int Suppl.
- Fine LG, Norman JT. Chronic hypoxia as a mechanism of kidney disease progression. Kidney Int.
- Haase VH. Hypoxia-inducible factors in kidney disease. J Am Soc Nephrol.
- Ruiz-Ortega M et al. TGF-ฮฒ signaling in renal fibrosis. Nat Rev Nephrol.
- Evenepoel P et al. The gut-kidney axis. Nat Rev Nephrol.
- Vaziri ND et al. CKD alters gut microbiome and toxin generation. Kidney Int.
- Tang WHW et al. Gut microbiota and cardiovascular disease (TMAO pathway). N Engl J Med.
๐น ๆ ขๆง่ ็พๆฃใใใณ็ท็ถญๅใซ้ขใใ่ฃ่ถณๆ็ฎ๏ผCKD and Fibrosis๏ผ
- Kalantar-Zadeh K et al. Chronic kidney disease. Lancet.
- Levin A et al. Kidney disease: global burden and management. Lancet.
- Ruiz S, Pergola PE, Zager RA. Targeting oxidative stress in CKD. Kidney Int.
- Nath KA. Tubulointerstitial changes as a major determinant in CKD. Kidney Int.
- Friedman SL et al. Mechanisms of fibrosis across organs. J Clin Invest.
ใ่ณชๅใฏใใใพใใ๏ผ
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- ๐ฏ๐ต ่ ๆฉ่ฝใจๅ จ่บซใฎๅฅๅบทใซ้ขใใ็ไฝ่ชฟ็ฏใกใซใใบใ ใฎ
- ใคใญใณใปใใซใดใชใณใฎๆฒป็ใฎๅบๆฌๅๅ
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- ืืืืืื ืชื ืืขื โ ืืชืงืืื ืืืืฉื ืืืืื ืืืืืช: ืชืจืืืืืช ืฉืืืงืืช ืืช ืฆืืจื ืืืืืื ืฉื ืคืขืืืืช ืืืคื ืืช
- ืืืืฃ ืืืืข ืขื ืืืืื: ืืืฆื ืืืืืช ืืืชื ืืืืฆืขืืช ืืื ืขืืืง ืืืืืงืืช ืืืขืืื ืืืชืกืืื ืื ืืืืคื ืืื
- ืืื ืืชืคืชืื ืืืืฆืืช ืืืืืื ืืืืช ืืืื ืืจืื ืืจืืืืื ืืืจืืฉืืื
- ืืืืื ืืืกืืกื ืืืืืืฆื โ ืื ืื ืืื ืื ื ืืื. ืื ืขืืื ืขื ืืืืืื ืืื ืื ืืืืืช? ืืืืฆืืืช ืืืืขื ืืชืืื ื ืืืื ืงืื ืืืืจืกืช ืืช ืืืืืืช
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- ืืฉืื ื ืืื ืืช โ ืกืืจืก ืืืืืืื โ ืื ืื ืื ืืขื ืฉืืกืืืจ ืืฉืื ื ืืื ืืช ืื ืืื ืืืืืช ืืชืจ. ืืื ืื ืืืจืืื ืืืื ืืชืืืืื ืืจืืื ืืกืืืจืื?
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