๐Ÿ”ท ื”ืžืกืœื•ืœื™ื ื”ื‘ื™ื•ืœื•ื’ื™ื™ื ืฉืžืฉืงืžื™ื ืืช ื”ื’ื•ืฃ: p53 โ€” ืฉื•ืžืจ ื”ื’ื ื•ื – ื—ืœืง ื“โ€™ โ€” ื™ืจื•ืŸ ืžืจื’ื•ืœื™ืŸ

ื›ืฉื ืฉืืœ ืคืขื ื”ืจืงื“ืŸ ื”ื™ืจื•ืฉืœืžื™ (ื‘ืื—ืช ื”ืกื“ื ืื•ืช ืฉื”ืขื‘ื™ืจ ืœืชืœืžื™ื“ื™ื•) ืฉืืœื” ืžื•ืจื›ื‘ืช ืขืœ ื—ื™ื™ ืื“ื, ื”ื•ื ืœื ืžื™ื”ืจ ืœืคืชื•ื— ืืช ืกืคืจื™ ื”ืœื™ืžื•ื“, ื’ื ืœื ืืช ื›ืชื‘ื™ ื”ื—ื›ืžื™ื.

ื‘ืžืงื•ื ื–ืืช ื”ืœืš ื‘ืจื’ืœ ืœื‘ื™ืชื•, ืฆืขื“ ืœืื•ืจืš ื”ื—ื•ืžื•ืช ืฉืœ ื”ืขื™ืจ ื”ืขืชื™ืงื”, ื”ืชื‘ื•ื ืŸ ื‘ืžื“ื‘ืจ ื™ื”ื•ื“ื”, ื•ื‘ื“ืง ืืช ืขืฆืžื•: "ื”ืื ื”ืฉืืœื” ื”ื–ื• ื ื•ื’ืขืช ื’ื ืืœื™ื™? ื”ืื ื’ื ืื ื™ ืฆืจื™ืš ืœืชืงืŸ ื›ืืŸ ืžืฉื”ื•?"

ืจืง ืื—ืจื™ ืฉื‘ื“ืง ืืช ืขืฆืžื• ื•ืชื™ืงืŸ ืืช ืžื” ืฉื ื“ืจืฉ ืœืชืงืŸ โ€” ื—ื–ืจ ื•ืขื ื”.


๐Ÿ”ท ื”ื”ึดืฉึฐืืชึธึผื”ื•ึผืช

ื™ืฉ ืจื’ืข ืฉื‘ื• ื”ื—ื™ื™ื ืื™ื ื ืžืชืงื“ืžื™ื โ€” ื”ื ืžืฉืชื”ื™ื. ืขื‘ื•ืจ ื”ืคื™ืœื•ืกื•ืคื™ื ื”ื™ื•ื•ื ื™ื, "ืคื ืื™"

ืกืงื•ืœื” (Schole) – ื”"ืคื ืื™" (ื‘ื™ื•ื•ื ื™ืช: Schole, ื”ืžืงื•ืจ ืœืžื™ืœื” School) ืœื ื”ื™ื” ืžื ื•ื—ื” ืคืกื™ื‘ื™ืช, ืืœื ื–ืžืŸ ืฉืžื•ืงื“ืฉ ืœืœืžื™ื“ื”, ื”ืชื‘ื•ื ื ื•ืช ื•ืฆืžื™ื—ื” ืจื•ื—ื ื™ืช ืœืœื ืœื—ืฅ ืฉืœ ืขื‘ื•ื“ื” ืื• ืฆืจื›ื™ื ื”ื™ืฉืจื“ื•ืชื™ื™ื. ื”ื”ึดืฉึฐืืชึธึผื”ื•ึผืช ื”ืชืงื‘ืœื” ื›ืžืฆื‘ ื”ืื™ื“ื™ืืœื™ ืฉืžืขื ื™ืง ืœืื“ื ื”ื–ื“ืžื ื•ืช ืœื”ืชื‘ื•ื ื ื•ืช ืžืขืžื™ืงื” (Contemplation) ื‘ืขื•ืœื, (Contemplation) ื•ื—ื™ืคื•ืฉ ืื—ืจ ืืžืช, ื™ื•ืคื™ ื•ื˜ื•ื‘, ืœืœื ืจื“ื™ืคื” ืื—ืจ ืชื•ืฆืื•ืช ืžื™ื™ื“ื™ื•ืช.

ืœื "ืขื™ื›ื•ื‘" (Delay) ืžืขื™ืง ืฉืžืคืจื™ืข ืœื–ืจื™ืžื”, ื•ื‘ื˜ื— ืฉืœื "ื—ืจื“ื”" (Anxiety) ืฉืœ ื—ื•ืกืจ ื•ื“ืื•ืช.
ืœื ื”ื™ื“ืจื“ืจื•ืช โ€”
ื’ื ืœื ืขืฆื™ืจื” ืื• ื“ืžื™ืžื”. ืœืคื™ ื’'ื•ืŸ ื“ื™ื•ืื™, ืžื—ืœื•ืฆื™ ื”ืคื™ืœื•ืกื•ืคื™ื” ืฉืœ ื”ื—ื™ื ื•ืš, ื”ื™ื ืจืคืœืงืฆื™ื”: "ืฉืงื™ืœื” ืคืขื™ืœื”, ืขืงื‘ื™ืช ื•ื–ื”ื™ืจื” ืฉืœ ื”ื™ื“ื•ืข. ืขืฆื™ืจื” ืžื›ื•ื•ื ืช ื›ื“ื™ ืœื‘ื“ื•ืง ืืช ื”ื™ืกื•ื“ื•ืช ืขืœื™ื”ื ื”ืžืฆื‘ ืืœื™ื• ื”ื’ืขื ื• ื ืฉืขืŸ.

ื‘ืชืจื‘ื•ื™ื•ืช ืจื‘ื•ืช ืชื™ืืจื• ืืช ื”ืจื’ืข ื”ื–ื” ื“ืจืš ื“ื™ืžื•ื™ ื—ื–ืง ืื—ื“:
ืขื•ืฃ ื”ื—ื•ืœ ื›ื–ื”ื• ื’ื ื—ืœื‘ื•ืŸ ื”ืคื•ืขืœ ื‘ื’ื•ืคื ื• ื‘ืฉื p53, ื ื•ืฉื ื—ืœืง ื“' ืฉืœ ืจืฆืฃ ื”ืžืืžืจื™ื ืขืœ ื›ื•ื—ื•ืช ื”ื”ื—ืœืžื” ื•ืฆื™ืจื™ ื”ื”ื—ืœืžื” ื”ื‘ื™ื•ืœื•ื’ื™ื™ื ืฉืคื•ืขืœื™ื ื‘ื’ื•ืคื ื•.

ื—ืœื‘ื•ืŸ p53 ืžื›ื•ื ื” "ืฉื•ืžืจ ื”ื’ื ื•ื" (Guardian of the Genome), ื•ื”ื“ืžื™ื•ืŸ ื‘ื™ื ื• ืœื‘ื™ืŸ ืžื•ืฉื’ ื”ืกืงื•ืœื” ื•ื”ื”ึดืฉึฐืืชึธึผื”ื•ึผืช ื ื™ื›ืจ ื‘ืฉืœื•ืฉื” ื”ื™ื‘ื˜ื™ื ืžืจื›ื–ื™ื™ื: [ืžืงื•ืจ1, ืžืงื•ืจ2, ืžืงื•ืจ3].

1. ื”ื”ืฉืชื”ื•ืช ื›"ื ืงื•ื“ืช ื‘ื™ืงื•ืจืช" (Checkpoint)

ื›ืžื• ืฉื”ืกืงื•ืœื” ืžืฉื”ื” ืืช ื”ืœื—ืฅ ืœื”ื™ื•ืช ื™ืฆืจื ื™ ื›ื“ื™ ืœืืคืฉืจ ืœืžื™ื“ื”, p53 ืžืฉื”ื” ืืช ืžื—ื–ื•ืจ ื”ืชื. [ืžืงื•ืจ1]

  • ื”ืคืขื•ืœื”: ื›ืฉืžื–ื•ื”ื” ื ื–ืง ื‘-DNA, ื—ืœื‘ื•ืŸ p53 ืขื•ืฆืจ ืืช ื—ืœื•ืงืช ื”ืชื ื‘ื ืงื•ื“ืช ื‘ื™ืงื•ืจืช (G1/S).
  • "ื”ื”ึดืฉึฐืืชึธึผื”ื•ึผืช" ื”ื‘ื™ื•ืœื•ื’ื™ืช ืฉื ื•ืฆืจืช ืื™ื ื” ืขื™ื›ื•ื‘ ืžืขื™ืง, ื“ืžื™ืžื”, ืื• ืชื’ื•ื‘ืช ื—ืจื“ื”, ืืœื ื”ึดืฉึฐืืชึธึผื”ื•ึผืช, ื”ืชื‘ื•ื ื ื•ืช ื—ื™ื•ื ื™ืช. ื”ืชื ืฉื•ืงืœ ืžื” ืขืœื™ื• ืœืขืฉื•ืช, ื›ื“ื™ ืœื”ืชื’ื‘ืจ ืขืœ ืžืืžืฆื™ ื”ืื“ื ืœื”ืจื•ืก ืืช ืžืขืจื›ืช ืฆื™ืจื™ ื”ื”ื—ืœืžื” ื‘ืขื–ืจืช ืชื–ื•ื ื” ื”ืจืคืชืงืื ื™ืช, ืื•ืคื ืชื™ืช ื•ื˜ืขื™ืžื” ื›ื“ื‘ืจื™ื•, ืื™ืš ืœื”ืขื‘ื™ืจ ื˜ืขื•ื™ื•ืช ื‘ื™ื•ืœื•ื’ื™ื•ืช ืฉื ื•ืฆืจื•ืช ื•ืžืงื“ืžื•ืช ืžื—ืœื” ื”ืœืื”. [ืžืงื•ืจ1, ืžืงื•ืจ2, ืžืงื•ืจ3]

2. ื‘ื™ืจื•ืจ ื”ื™ื›ืŸ ื˜ืขื™ื ื• ื›ื“ื™ ืœืฉืคืจ (Repair)

ืžื ื’ื ื•ื ื™ ื”ืชื™ืงื•ืŸ [ืžืงื•ืจ1, ืžืงื•ืจ2].

  • ื”ืคืขื•ืœื”: ื‘ืžื”ืœืš ื”ืขืฆื™ืจื”, p53 ืžื’ื™ื™ืก ื—ืœื‘ื•ื ื™ื ืฉืžืชืงื ื™ื ืืช ื”-DNA ื”ืคื’ื•ื.
  • ื”ื”ืงื‘ืœื”: ื–ื•ื”ื™ ื”ืจืคืœืงืฆื™ื” ื”ืœื›ื” ืœืžืขืฉื”. p53 ืœื ืจืง ืื•ืžืจ "ื™ืฉ ื˜ืขื•ืช", ื”ื•ื ืžืืคืฉืจ ืืช ื”ืžืจื—ื‘ (ื”ื–ืžืŸ) ื•ื”ื›ืœื™ื ืœื‘ื—ื•ืŸ ืืช ื”ืžืฆื‘ ืžื—ื“ืฉ ื•ืœืชืงืŸ ืื•ืชื• ืœืคื ื™ ืฉืžืžืฉื™ื›ื™ื ื‘ื—ื™ื™ื (ื‘ื—ืœื•ืงืช ื”ืชื). [ืžืงื•ืจ1, ืžืงื•ืจ2, ืžืงื•ืจ3].

3. ื”ื‘ื ืช ื”"ื ื›ื•ืŸ" ื•ื”ื›ืจืขื” (Cell Fate)

p53 ื”ื•ื ื”"ืคื™ืœื•ืกื•ืฃ" ืฉืœ ื”ืชื โ€“ ื”ื•ื ื”ืฉื•ืžืจ ื”ืืคืœื˜ื•ื ื™ ื•ืžื™ ืฉืฆืจื™ืš ืœื”ื›ืจื™ืข ืžื”ื• ื”ื ืชื™ื‘ ื”ื ื›ื•ืŸ. [ืžืงื•ืจ1, ืžืงื•ืจ2].

  • ื”ืคืขื•ืœื”: ืื ื”ื ื–ืง ื ื™ืชืŸ ืœืชื™ืงื•ืŸ, p53 ืžืืคืฉืจ ืœืชื ืœื”ืžืฉื™ืš ื•ืœื’ื•ืฃ ืœืชืงืŸ. ืื ื”ื ื–ืง ื—ืžื•ืจ ืžื“ื™ ื•ื”ืชื™ืงื•ืŸ ื™ื•ืœื™ื“ ืฉื™ื‘ื•ืฉ (ืกืจื˜ืŸ), ื”ื•ื ืžื•ื‘ื™ืœ ืืช ื”ืชื ืœืืคื•ืคื˜ื•ื–ื™ืก (ืžื•ื•ืช ืชืื™ ืžืชื•ื›ื ืŸ) โ€“ ื”ืงืจื‘ืช ื”ืคืจื˜ ืœืžืขืŸ ืชืงื™ื ื•ืช ื”ืžืขืจื›ืช ื›ื•ืœื”.
  • ื–ื•ื”ื™ ื”ืฉืžื™ืจื” ื”ืžืขืœื”, ื”ื—ืชื™ืจื” ืœืืžืช (ื”ื‘ื ืช ื”ื ื›ื•ืŸ). ื”ื”ืฉื”ื™ื™ื” ื‘ืกืงื•ืœื” ืžื•ืคื™ืขื” ื›ืืŸ. ื”ื™ื ื ื•ืขื“ื” ืœื‘ืจืจ ืžื” ื ื›ื•ืŸ ื•ืžื” ื˜ืขื•ืช. p53 ืžื•ื•ื“ื ืฉืจืง ืžื” ืฉ"ื ื›ื•ืŸ" (DNA ืชืงื™ืŸ) ื™ืžืฉื™ืš ื”ืœืื”. [ืžืงื•ืจ1, ืžืงื•ืจ2, ืžืงื•ืจ3]

ืกื™ื›ื•ื ื”ื”ืฉื•ื•ืื”

ื”ื™ื‘ื˜ ืžืงื•ืจ1,] ืžืงื•ืจ2].ืกืงื•ืœื” / ืจืคืœืงืฆื™ื”ื—ืœื‘ื•ืŸ p53
ื”ืžืฆื‘ื”ืฉืชื”ื•ืช (ื ื™ื ื•ื—ื•ืช, ืขืฆื™ืจืช ื”ืžืจื•ืฅ)Cell Cycle Arrest (ืขืฆื™ืจืช ื—ืœื•ืงืช ื”ืชื)
ื”ืžื˜ืจื”ื‘ื™ืจื•ืจ ื•ืชื™ืงื•ืŸ (ื”ื™ื›ืŸ ื˜ืขื™ื ื•, ืื™ืš ืœืฉืคืจ)DNA Repair (ื–ื™ื”ื•ื™ ืฉื‘ืจื™ื ื•ืชื™ืงื•ื ื)
ื”ืชื•ืฆืื”ืฆืžื™ื—ื” ืžืชื•ืš ืืžืช (ื”ื‘ื ืช ื”ื ื›ื•ืŸ)Genomic Stability (ืฉืžื™ืจื” ืขืœ ื’ื ื•ื ืชืงื™ืŸ)

ื›ืืฉืจ p53 ืคื’ื•ื (ืžื•ื˜ืฆื™ื”), ื”ืชื ืžืื‘ื“ ืืช ื”ื™ื›ื•ืœืช ืœื”ืฉืชื”ื•ืช, ืžืชืขืœื ืžื”ื˜ืขื•ื™ื•ืช ื•ืžืžืฉื™ืš ืœื”ืฉืชื›ืคืœ ื‘ืคืจืื•ืช โ€“ ื•ื–ื”ื• ื‘ื“ื™ื•ืง ื”ืชื”ืœื™ืš ื”ืกืจื˜ื ื™. ื–ื”ื• ืžืฉืœ ืžืจืชืง ืœื—ื‘ืจื” ืื• ืœืื“ื ืฉืžืื‘ื“ื™ื ืืช ื”"ืกืงื•ืœื”" ืฉืœื”ื: ื”ื ืžืžืฉื™ื›ื™ื ืœืจื•ืฅ ืงื“ื™ืžื” ืขื ื”ื˜ืขื•ื™ื•ืช ืฉืœื”ื, ืžื‘ืœื™ ืœืขืฆื•ืจ ืœืชืงืŸ, ืขื“ ืœืงืจื™ืกืช ื”ืžืขืจื›ืช [ืžืงื•ืจ1, ืžืงื•ืจ2].

ื”ืื ืชืจืฆื” ืฉื ื‘ื“ื•ืง ืื™ืš "ื—ืœื‘ื•ืŸ ื”-p53 ื”ืชื•ื“ืขืชื™" ืฉืœื ื• ื™ื›ื•ืœ ืœืคืขื•ืœ ื˜ื•ื‘ ื™ื•ืชืจ ื‘ื™ื•ืžื™ื•ื?

ืขื•ืฃ ื”ื—ื•ืœ ๐Ÿฆโ€๐Ÿ”ฅ ื”ืžื™ืชื•ืœื•ื’ื™ ืฉื‘ ื•ื ื•ืœื“ ื”ื•ื ืื™ื ื• ื ืœื—ื ื‘ืžืฆื‘ ื”ืงืฉื”.
ื”ื•ื ืžืืคืฉืจ ืœืืฉ ืœืคืขื•ืœ.
ื—ื•ืฉืฃ ืืช ืžืจื›ื™ื‘ื™ื• ื”ื—ื™ื•ื ื™ื™ื ื‘ื™ื•ืชืจ โ€” ื•ืžืชื•ืš ื”ืืคืจ ื”ื•ื ื ื‘ื ื” ืžื—ื“ืฉ.

ืœื ื›ื”ืžืฉืš ื™ืฉื™ืจ ืœื™ืฉ ื”ื™ืฉืŸ โ€”
ืืœื ื›ื”ืชื—ืœื” ืžื“ื•ื™ืงืช ื™ื•ืชืจ. ืจื ืกื ืก, ืฉื™ื‘ืช ืฆื™ื•ืŸ.


ื›ื–ื”ื• ื’ื ืื—ื“ ื”ืžื ื’ื ื•ื ื™ื ื”ืขืžื•ืงื™ื ื‘ื™ื•ืชืจ ื‘ื’ื•ืฃ:

p53 โ€” ืฉื•ืžืจ ื”ื’ื ื•ื.

ื›ืืฉืจ ื”ืชื ืžื–ื”ื” ืขื•ืžืก, ื ื–ืง ืื• ืกื˜ื™ื™ื” ืžื”ืื™ื–ื•ืŸ,
ื”ื•ื ืื™ื ื• ืžืžืฉื™ืš ืœืคืขื•ืœ ื›ืจื’ื™ืœ.

๐Ÿ‘‰ ื”ื•ื ืขื•ืฆืจ.

ืžืืคืฉืจ ืœืžื ื’ื ื•ื ื™ ื”ื‘ื“ื™ืงื” ื•ื”ืชื™ืงื•ืŸ ืœืคืขื•ืœ,
ื•ืจืง ืœืื—ืจ ืžื›ืŸ โ€” ืžืžืฉื™ืš.


ื”ืขืฆื™ืจื” ื”ื–ื• ื”ื™ื ืชื ืื™ ืœื”ื™ืฉืจื“ื•ืชื•. ื‘ื™ื˜ื•ื™ ืœืขื•ืฆืžื”.

ื”ื™ื ื”ื‘ื—ื™ืจื” ืฉืœื ืœื”ืžืฉื™ืš ืœื‘ื ื•ืช
ื›ืืฉืจ ื”ื™ืกื•ื“ื•ืช ืื™ื ื ื™ืฆื™ื‘ื™ื.


๐Ÿ”ถ ืื‘ืœ ื›ืืŸ ืžืชื’ืœื” ื”ืงื•ืฉื™

ื”ื’ื•ืฃ ืื™ื ื• ืคื•ืขืœ ืจืง ื‘ื›ื™ื•ื•ืŸ ืื—ื“.

ื‘ืžืงื‘ื™ืœ ืœืžื ื’ื ื•ืŸ ื”ื‘ืœื™ืžื”,
ืคื•ืขืœ ื‘ื• ื’ื ืžื ื’ื ื•ืŸ ืื—ืจ โ€”
ืžื ื’ื ื•ืŸ ืฉืœ ืฉืคืข, ื‘ื ื™ื™ื” ื•ื’ื“ื™ืœื”.

ืžืกืœื•ืœ ื–ื” ืžื•ื›ืจ ื‘ืฉื:

PI3K โ†’ Akt โ†’ mTOR


ื›ืืฉืจ ื”ื•ื ืคื•ืขืœ ื‘ืฆื•ืจื” ืžืื•ื–ื ืช โ€”
ื”ื•ื ื—ื™ื•ื ื™ ืœื—ื™ื™ื.

ื”ื•ื ืžืืคืฉืจ:

  • ื‘ื ื™ื™ื” ืฉืœ ืจืงืžื•ืช
  • ื™ืฆื™ืจืช ื—ืœื‘ื•ื ื™ื
  • ื”ืชื—ื“ืฉื•ืช

๐Ÿ”ด ืืš ื›ืืฉืจ ืื™ืŸ ื”ืคืกืงื”

ื›ืืฉืจ ื”"ืฉืคืข" (ืกื˜ื™ืงื™ื, ืฆ'ื™ืคืก, ืขืœ ื”ืืฉ, ืขื•ื’ื•ืช, ืžืฉืงืื•ืช ืžืžื•ืชืงื™ื… ืืœื›ื•ื”ื•ืœ) ืžืชืžืฉืš ืœืœื ืขืฆื™ืจื” โ€”

  • ืขื•ื“ืฃ ืžื–ื•ืŸ
  • ืขื•ืžืก ืกื•ื›ืจ
  • ืื•ืชื•ืช ื’ื“ื™ืœื” ืจืฆื™ืคื™ื
  • ื›ื“ื•ืจื™ื ื ื’ื“ ื›ืื‘
  • ื›ื“ื•ืจื™ื ื ื’ื“ ื›ื•ืœืกื˜ืจื•ืœ
  • ื›ื“ื•ืจื™ื ื ื’ื“ ื™ืชืจ ืœื—ืฅ ื“ื
  • ื›ื“ื•ืจื™ื ื ื’ื“ ืกื•ื›ืจืช

ื”ืžืขืจื›ืช ืžืžืฉื™ื›ื” ืœื‘ื ื•ืช โ€”
ื’ื ื›ืืฉืจ ื”ืชื ืื™ื ืื™ื ื ืžืชืื™ืžื™ื. ื”ืชื ื‘ื•ื ื”, ื•ื‘ื•ื ื”, ื•ืžื” ื”ื•ื ื‘ื•ื ื”โ“


ื•ื›ืืŸ ื ื›ื ืก ืฉื•ื‘ ืื•ืชื• ืžื ื’ื ื•ืŸ ืฉืงื˜ ืฉืœ ื”ื”ืชื‘ื•ื ื ื•ืช๐Ÿฆโ€๐Ÿ”ฅ, ืขื•ืฃ ื”ื—ื•ืœ ื”ื‘ื™ื•ืœื•ื’ื™ ื” – :

p53 ๐Ÿฆโ€๐Ÿ”ฅ

๐Ÿ‘‰ ืœื ื›ื“ื™ ืœืขืฆื•ืจ ืืช ื”ืชืคืงื•ื“, ืœื ื›ื“ื™ ืœื—ื ืš โ€”
ืืœื ื›ื“ื™ ืœื”ื’ืŸ ืขืœ ื”ืงื™ื™ื.

ื”ื•ื ืžืื•ืชืช:

ืขืฆื•ืจ.
ื‘ื“ื•ืง.
ืชืงืŸ.

ื•ืื™ืŸ ืฉื•ืžืข


๐Ÿ”ป ื”ื‘ืขื™ื” ื”ืืžื™ืชื™ืช

๐Ÿ‘‰ ื”ื‘ืขื™ื” ื”ื™ื ื‘ื›ืš ืฉืื™ืŸ ืœื• ื”ืฉืคืขื” ืขืœ ื”ืืžื•ื ื”, ืขืœ ื”ืœื ืงื™ื™ื, ืขืœ ืขืจื•ืฆื™ ื”ื˜ืœื•ื™ื–ื™ื”, ืขืœ ื”ืกื•ื›ืจ, ืขืœ ื”ืžืœื—… ื•ืœื›ืŸ ื”ื•ื ื ืืœืฅ ืœืขืฆื•ืจ ืฉื•ื‘ ื•ืฉื•ื‘.

ื›ืืฉืจ ื–ื” ืงื•ืจื” โ€”
ื–ื”ื• ืกื™ืžืŸ ืฉื”ืขื•ืžืก, ืฉื”ืื“ื ื”ืžืืžื™ืŸ ื‘ืชื–ื•ื ื” ื”ืื•ืคื ืชื™ืช, ื”ื˜ืขื™ืžื”, ื”ื”ืจืกื ื™ืช ื’ื“ื•ืœ ืžื“ื™, ืื‘ืœ ื”ืื“ื ื‘ืฉืœื•… ื”ืจื•ืคื ืœื ื‘ื“ื™ื•ืง ืงื•ืœื˜ ืžื” ืงื•ืจื” ื‘ืืžืช…


๐Ÿ”ท๐Ÿฅ— ื”ืžื–ื•ืŸ ื›ืชืจื•ืคื”

ื›ื“ื™ ืœื”ื‘ื™ืŸ ืžื” ื™ื•ืฆืจ ืืช ื”ืขื•ืžืก ื”ื–ื”,
ื™ืฉ ืœื”ืขืžื™ืง ื‘ืžืกืœื•ืœ ื”ืฉืคืข ืขืฆืžื• โ€” ืœื”ื‘ื™ืŸ ืžื” ืžืคืขื™ืœ ืืช ื”ืžื—ืœื” ื•ืžื” ืžืคืขื™ืœ ืืช ื”ืชื—ื–ื•ืงื” ื”ืฉืงื˜ื”, ื•ืืช ื”ื”ื—ืœืžื”.

๐Ÿ‘‰ ื›ื™ืฆื“ ื”ื’ื•ืฃ ืคื•ืขืœ
๐Ÿ‘‰ ื•ืžื“ื•ืข ื”ื•ื ื™ื•ืฆื ืžืื™ื–ื•ืŸ

ืขืœ ื›ืš ื‘ืžืืžืจื™:

ื›ื™ืฆื“ P53 ืคื•ืขืœโ“

ื›ืืฉืจ ื—ืœื‘ื•ืŸ p53 (ื”ืžื›ื•ื ื” "ืฉื•ืžืจ ื”ื’ื ื•ื") ืžื–ื”ื” ื ื–ืง ื‘-DNA, ื”ื•ื ืคื•ืขืœ ื‘ืžื ื’ื ื•ืŸ ื“ื•-ืฉืœื‘ื™ ืžื“ื•ื™ืง ืฉื ื•ืขื“ ืœืฉืžื•ืจ ืขืœ ืชืงื™ื ื•ืช ื”ืชื ื•ืžื ืกื” ืœืขืฆื•ืจ, ื‘ืชืงื•ื” ืœืžื ื•ืข ืกืจื˜ืŸ

[ืžืงื•ืจ1, ืžืงื•ืจ2].

1. ื”ืฉื”ื™ื” (Cell Cycle Arrest)

ื›ื“ื™ ืœืžื ื•ืข ืžื”ืชื ืœืฉื›ืคืœ DNA ืคื’ื•ื ื•ืœื”ืขื‘ื™ืจื• ื”ืœืื”, p53 ืขื•ืฆืจ ืืช "ืžื—ื–ื•ืจ ื”ืชื": [ืžืงื•ืจ1, ืžืงื•ืจ2]

  • ื”ืคืขืœืช p21: ื—ืœื‘ื•ืŸ p53 ืคื•ืขืœ ื›ื’ื•ืจื ืฉืขืชื•ืง ื•ืžืคืขื™ืœ ืืช ื”ื’ืŸ ื”ืžื™ื™ืฆืจ ืืช ื”ื—ืœื‘ื•ืŸ p21.
  • ืขืฆื™ืจืช ื”ืžื ื•ืข ื”ืชืื™: ื—ืœื‘ื•ืŸ p21 ื ืงืฉืจ ืœืื ื–ื™ืžื™ื (CDKs) ืฉืื—ืจืื™ื ืขืœ ื”ืชืงื“ืžื•ืช ืžื—ื–ื•ืจ ื”ืชื ื•ืžื ื˜ืจืœ ืื•ืชื.
  • ื”ืชื•ืฆืื”: ื”ืชื ื ืขืฆืจ ื‘ื ืงื•ื“ืช ื‘ื™ืงื•ืจืช (ื‘ื“ืจืš ื›ืœืœ ื‘ืฉืœื‘ G1), ืžื” ืฉืžืขื ื™ืง ืœื• ืืช "ื”ื–ืžืŸ" ื”ื“ืจื•ืฉ ืœื‘ื“ื™ืงื” ื•ืชื™ืงื•ืŸ ืœืคื ื™ ื”ื—ืœื•ืงื”. [ืžืงื•ืจ1, ืžืงื•ืจ2, ืžืงื•ืจ3, ืžืงื•ืจ4, ืžืงื•ืจ5]

2. ื”ืคืขืœืช ืžื ื’ื ื•ื ื™ ืชื™ืงื•ืŸ (DNA Repair)

ื‘ื–ืžืŸ ืฉื”ืชื ื ืžืฆื ื‘"ื”ืฉื”ื™ื”", p53 ื“ื•ืื’ ืœืชื™ืงื•ืŸ ื”ื ื–ืง ื‘ืื•ืคืŸ ืืงื˜ื™ื‘ื™: [ืžืงื•ืจ1, ืžืงื•ืจ2, ืžืงื•ืจ3]

  • ื’ื™ื•ืก ืฆื•ื•ืชื™ ืชื™ืงื•ืŸ: p53 ืžืขื•ืจืจ ืฉืขืชื•ืง ืฉืœ ื’ื ื™ื ื”ืžืงื•ื“ื“ื™ื ืœื—ืœื‘ื•ื ื™ื ื”ืžืชืžื—ื™ื ื‘ืชื™ืงื•ืŸ DNA, ื›ืžื• ื—ืœื‘ื•ื ื™ื ืžืžืฉืคื—ืช GADD45.
  • ืกื•ื’ื™ ืชื™ืงื•ืŸ: ื”ื•ื ืžืคืขื™ืœ ืžืขืจื›ื•ืช ืฉื•ื ื•ืช ื‘ื”ืชืื ืœืกื•ื’ ื”ื ื–ืง, ื›ื•ืœืœ ืชื™ืงื•ืŸ ืฉื‘ืจื™ื ื‘-DNA ื•ืชื™ืงื•ืŸ ื˜ืขื•ื™ื•ืช ื‘ื‘ืกื™ืกื™ ื”-DNA (ื›ืžื• ืžื ื’ื ื•ื ื™ NER ื•-BER).
  • ื”ื”ื›ืจืขื”: ืื ื”ืžื ื’ื ื•ื ื™ื ืžืฆืœื™ื—ื™ื ืœืชืงืŸ ืืช ื”ื ื–ืง, p53 "ืžืฉื—ืจืจ" ืืช ื”ืขืฆื™ืจื” ื•ื”ืชื ืžืžืฉื™ืš ื‘ื—ืœื•ืงื”. ืื ื”ื ื–ืง ื—ืžื•ืจ ืžื“ื™ ื•ืื™ื ื• ื ื™ืชืŸ ืœืชื™ืงื•ืŸ, p53 ื™ืคืขื™ืœ ืžืกืœื•ืœ ืฉืœ ืžื•ื•ืช ืชืื™ ืžืชื•ื›ื ืŸ (ืืคื•ืคื˜ื•ื–ื™ืก) ื›ื“ื™ ืœื”ืฉืžื™ื“ ืืช ื”ืชื ื”ืคื’ื•ื. [ืžืงื•ืจ1, ืžืงื•ืจ2, ืžืงื•ืจ3, ืžืงื•ืจ4, ืžืงื•ืจ5, ืžืงื•ืจ6].

ืžื” ืงื•ืจื” ื›ืืฉืจ ืžื ื’ื ื•ืŸ ื”-p53 ื ืคื’ื ื•ืื™ื ื• ืžืฆืœื™ื— ืœื‘ืฆืข ืืช ื”ืขืฆื™ืจื” ื”ื–ื•

ื›ืืฉืจ ืžื ื’ื ื•ืŸ ื”-p53 ื ืคื’ื (ื‘ื“ืจืš ื›ืœืœ ืขืงื‘ ืžื•ื˜ืฆื™ื” ื’ื ื˜ื™ืช), ื”ืชื ืžืื‘ื“ ืืช ื”"ื‘ืœืžื™ื" ืฉืœื• ื•ืืช ื™ื›ื•ืœืช ื”ื‘ื™ืงื•ืจืช. ื”ืชื•ืฆืื” ื”ื™ื ืฉืจืฉืจืช ืื™ืจื•ืขื™ื ื”ืจืกื ื™ืช:

  1. ืื•ื‘ื“ืŸ ื”"ืกืงื•ืœื”" (ื”ื”ืฉืชื”ื•ืช): ื”ืชื ืื™ื ื• ืขื•ืฆืจ ื‘ื ืงื•ื“ื•ืช ื”ื‘ื™ืงื•ืจืช. ื’ื ืื ื”-DNA ืคื’ื•ื, ื”ืชื ืžืžืฉื™ืš ืœื”ืฉืชื›ืคืœ ืœืœื ื”ืคืกืงื”. ื–ื”ื• ืžืฆื‘ ืฉืœ "ืจื™ืฆื” ืขื™ื•ื•ืจืช".
  2. ื”ืฆื˜ื‘ืจื•ืช ืžื•ื˜ืฆื™ื•ืช: ืžื›ื™ื•ื•ืŸ ืฉืžื ื’ื ื•ื ื™ ื”ืชื™ืงื•ืŸ ืœื ื”ื•ืคืขืœื•, ื˜ืขื•ื™ื•ืช ื”ื”ืขืชืงื” ื”ื•ืคื›ื•ืช ืœืงื‘ื•ืขื•ืช. ื›ืœ ื“ื•ืจ ื—ื“ืฉ ืฉืœ ืชืื™ื ื ื•ืฉื ื™ื•ืชืจ "ืฉื’ื™ืื•ืช ื›ืชื™ื‘" ื’ื ื˜ื™ื•ืช ืžืงื•ื“ืžื•.
  3. ื”ืชื—ืžืงื•ืช ืžืžื•ื•ืช ืชืื™: ื‘ืžืฆื‘ ืชืงื™ืŸ, ืชื ืคื’ื•ื ืžืื•ื“ ืืžื•ืจ ืœื”ืชืื‘ื“ (ืืคื•ืคื˜ื•ื–ื™ืก). ื›ืฉ-p53 ืคื’ื•ื, ื”ืคืงื•ื“ื” ื”ื–ื• ืœื ื ื™ืชื ืช, ื•ื”ืชื ื”ื•ืคืš ืœ"ืืœืžื•ืชื™" ื‘ืžื•ื‘ืŸ ื”ืฉืœื™ืœื™ โ€“ ื”ื•ื ืžืžืฉื™ืš ืœื—ื™ื•ืช ื•ืœืฉื’ืฉื’ ืœืžืจื•ืช ื”ื™ื•ืชื• ืคื’ื•ื ื•ืžืกื•ื›ืŸ.
  4. ื”ืชืคืชื—ื•ืช ืกืจื˜ืŸ: ื”ืฉื™ืœื•ื‘ ืฉืœ ื—ืœื•ืงื” ืžื”ื™ืจื”, ื—ื•ืกืจ ืชื™ืงื•ืŸ ื•ืื™-ื™ื›ื•ืœืช ืœืžื•ืช ืžื•ื‘ื™ืœ ืœื™ืฆื™ืจืช ื’ื™ื“ื•ืœ ืžืžืื™ืจ. ืœืžืขืฉื”, ืžื•ื˜ืฆื™ื•ืช ื‘ื—ืœื‘ื•ืŸ p53 ื ืžืฆืื•ืช ื‘ื›-50% ืžื›ืœืœ ืกื•ื’ื™ ื”ืกืจื˜ืŸ ื‘ื‘ื ื™ ืื“ื.

ื‘ื ืžืฉืœ ื”ืชื•ื“ืขืชื™ ืฉืœื ื•: ืื“ื ืฉืžืื‘ื“ ืืช ื™ื›ื•ืœืช ื”-p53 ืฉืœื• ื”ื•ื ืื“ื ืฉืจืฅ ื‘ื—ื™ื™ื ืžื‘ืœื™ ืœืขืฆื•ืจ ืœื‘ื—ื•ืŸ ื˜ืขื•ื™ื•ืช. ื”ื•ื ื—ื•ื–ืจ ืขืœ ืื•ืชืŸ ืฉื’ื™ืื•ืช, ืฆื•ื‘ืจ "ื ื–ืงื™ื" ื ืคืฉื™ื™ื ืื• ืžืงืฆื•ืขื™ื™ื, ื•ืื™ื ื• ืžืกื•ื’ืœ ืœื‘ืฆืข ืชื™ืงื•ืŸ (Refinement), ืžื” ืฉืžื•ื‘ื™ืœ ื‘ืกื•ืคื• ืฉืœ ื“ื‘ืจ ืœืงืจื™ืกืช ื”ืžืขืจื›ืช ื”ืื™ืฉื™ืช ืฉืœื•.

ื›ืฉืื ื• ืžืฉืคืจื™ื ืืช ื”ืชื–ื•ื ื”, ืื ื• ืžืืคืฉืจื™ื ืœ-p53 ื•ืœืžืกืœื•ืœื™ ื”ื”ื—ืœืžื” ืœืขื‘ื•ื“ ื‘ื™ืขื™ืœื•ืช โ€“ ื•ืœื”ืคื•ืš ืขืฆื™ืจื” ื–ืžื ื™ืช ืœื”ืชื—ื“ืฉื•ืช ืืžื™ืชื™ืช. ื™ืจื•ืŸ ืžืจื’ื•ืœื™ืŸ

ื™ืจื•ืŸ ืžืจื’ื•ืœื™ืŸ

ื ืฉืืจื• ืœืš ืฉืืœื•ืช

๐Ÿ”ฌืืฉืžื— ืœื”ืฉื™ื‘ ืขืœ ื›ืœ ืฉืืœื”

ื‘ื‘ืงืฉื” ืœื ืœื”ืชืงืฉืจ ืžืฉื•ื ืฉื–ื” ืคืฉื•ื˜ ืœื ืžืืคืฉืจ ืœื™ ืœืขื‘ื•ื“ โ€“ ืื ื ื”ืฉืชืžืฉื• ื‘ืืžืฆืขื™ื ืฉืœืคื ื™ื›ื

    ืฉืžื™ Name:


    ื˜ืœืคื•ืŸ phone:


    ื“ื•ื"ืœ (ื›ื“ื™ ืฉืื•ื›ืœ ืœื”ืฉื™ื‘ ืœืš ืžื›ืœ ืžืงื•ื ื‘ืขื•ืœื) Email:


    ืื™ืš ืื ื™ ื™ื›ื•ืœ ืœืขื–ื•ืจ ืœืš How can I help you:


    ืืคืฉืจ ืœืงื‘ืœ ืืช ื‘ื“ื™ืงื•ืช ื”ื“ื ื”ื—ืจื™ื’ื•ืช ืฉืœืš Exceptional laboratory tests:


    ืœืžืขืŸ ื”ืกืจ ืกืคืงื—ื•ื‘ืช ื”ืชื™ื™ืขืฆื•ืช ืขื ืจื•ืคื (ื”ืžื›ื™ืจ ืœืคืจื˜ื™ื ืืช ืžืฆื‘ื• ื”ื‘ืจื™ืื•ืชื™ ื”ื›ืœืœื™ ืฉืœ ื›ืœ ืžื˜ื•ืคืœ ืื• ืฉืœืš) ืœืคื ื™ ืฉื™ืžื•ืฉ ื‘ื›ืœ ืชื›ืฉื™ืจ, ืžืื›ืœ, ืชืžืฆื™ืช ืื• ื‘ื™ืฆื•ืข ื›ืœ ืชืจื’ื™ืœ. ื™ืจื•ืŸ ืžืจื’ื•ืœื™ืŸ ื”ื•ื ืจืงื“ืŸ ื•ืžื‘ื™ืช ื”ืžื—ื•ืœ ืฉืœื• ื‘ื™ืจื•ืฉืœื™ื ืคืจืฆื” ื”ืชื•ืจื” ื›ืืฉืจ ื ื—ืฉืคื” ืฉื™ื˜ืช ื”ืžื—ื•ืœ ืฉืœื• ื›ื‘ืขืœืช ื™ื›ื•ืœืช ืžื“ื”ื™ืžื”, ื‘ืืžืฆืข ืฉื ื•ืช ื” โ€“ 80 ืœืจืคื ืกืจื˜ืŸ. ื”ืžื™ื“ืข ื‘ืืชืจ ืฉืœ ื™ืจื•ืŸ ืžืจื’ื•ืœื™ืŸ ืื• ื‘ืืชืจ "ืœื—ื™ืฆื•ืช ื”ื”ื—ืœืžื”" (ื‘ืคื™ืกื‘ื•ืง ืื• MARGOLINMETHOD.COM ), ื‘ืžืืžืจ ื”ื "ืœ ื•ื‘ืžืืžืจื™ื ืฉืœ ื™ืจื•ืŸ ืžืจื’ื•ืœื™ืŸ ื”ื ื—ื•ืžืจ ืœืžื—ืฉื‘ื” โ€“ ืคื™ืœื•ืกื•ืคื™ื” ืœื ื”ืžืœืฆื” ื•ืœื ื”ื ื—ื™ื™ื” ืœืฆื™ื‘ื•ืจ ืœื”ืฉืชืžืฉ ืื• ืœื—ื“ื•ืœ ืžืœื”ืฉืชืžืฉ ื‘ืชืจื•ืคื•ืช โ€“ ืื™ืŸ ื‘ืžื™ื“ืข ื‘ืืชืจ ื–ื” ืื• ื‘ื›ืœ ืื—ื“ ืžื”ืžืืžืจื™ื ืชื—ืœื™ืฃ ืœื”ื™ื•ื•ืขืฆื•ืช ืขื ืžื•ืžื—ื” ืžื•ื›ืจ ื”ืžื›ื™ืจ ืœืคืจื˜ื™ื ืืช ืžืฆื‘ื• ื”ื‘ืจื™ืื•ืชื™ ื”ื›ืœืœื™ ืฉืœืš ื•ืฉืœ ืžืฉืคื—ืชืš. ืžื•ืžืœืฅ ืชืžื™ื“ ืœื”ืชื™ื™ืขืฅ ืขื ืจื•ืคื ืžื•ืกืžืš ืื• ืจื•ืงื— ื‘ื›ืœ ื”ื ื•ื’ืข ื‘ื›ืื‘, ื”ืจื’ืฉื” ืจืขื” ืื• ืœืžื˜ืจื•ืช ื•ืื•ืคืŸ ื”ืฉื™ืžื•ืฉ, ื‘ืžื–ื•ื ื•ืช, ืžืฉื—ื•ืช, ืชืžืฆื™ื•ืช ื•ืืคื™ืœื• ื‘ืชืจื’ื™ืœื™ื, ืื• ื‘ืชื›ืฉื™ืจื™ื ืื—ืจื™ื ืฉื ื–ื›ืจื™ื ื›ืืŸ.

     physician (who knows in detail the general health of each patient or yours) before using any medicine, food, extract or any exercise. The information on Yaron Margolin's website or the "Healing Presses" website (on Facebook or YARONMARGOLIN.COM), in the above article and in Yaron Margolin's articles are material for thought โ€“ philosophy neither recommendation nor public guidance to use or cease to use drugs โ€“ no information on this site or anyone You should always consult with a qualified physician or pharmacist regarding pain, bad feeling, or goals and how to use foods, ointments, extracts and even exercises, or other remedies that are mentioned as such

    ืžืืžืจื™ื ืื—ืจื•ื ื™ื

    ื ืฉืœื— ื‘ ื›ืœืœื™

    ื›ืชื™ื‘ืช ืชื’ื•ื‘ื”

    Or

    ื”ืื™ืžื™ื™ืœ ืœื ื™ื•ืฆื’ ื‘ืืชืจ. ืฉื“ื•ืช ื”ื—ื•ื‘ื” ืžืกื•ืžื ื™ื *

    *